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. 2019 Apr 2;33(6):7126–7142. doi: 10.1096/fj.201801526RR

Figure 7.

Figure 7

Metabolite composition of the cecum content collected from KHK−/− or WT mice fed 20% fructose diet for 3 wk with (KHK-F + AB or WT-F + AB) or without (KHK-F or WT-F) AB treatment (n = 5–7/group). A) SCFA quantification in cecum content by gas chromatography. B) PCA score plots obtained from 1H-NMR spectra of cecum content extracts from KHK-F, KHK-F + AB, WT-F, and WT-F + AB. C) Plots of O-PLS-DA coefficients related to the discrimination between 1H-NMR spectra of cecum content extracts from WT-F vs. KHK-F. D) Plots of O-PLS-DA coefficients related to the discrimination between 1H-NMR spectra of cecum content extracts from WT-F + AB vs. KHK-F + AB. E) Bar graph representation of the relative integral for different metabolites (glucose, lactate, alanine, and succinate) in cecum content. AUC, area under the curve. All values are means ± sem. Means were compared by 1-way ANOVA followed by Tukey’s post hoc test. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.