Figure 8.

DCA modifies pyruvate and lactate levels oppositely from the effect of pyruvate addition. (a) Pyruvate and (b) lactate levels (means ± SD, n ≥ 3, generally four batches for each group) in L3 larvae of the indicated genotypes (OR = Oregon R wild-type). HS – high-sugar medium, ZS – zero-sugar medium, DCA – with addition of 12.5 mg/ml DCA, pyr, lac – with addition of 25 mg/ml pyruvate or lactate, respectively. Data are normalized to the values for wild-type on ZS medium. For statistical analysis, see Tables S3. For a summary diagram of the reactions targeted by drugs and RNAi see Figure 10.