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. 2006 Apr 19;2006(2):CD003558. doi: 10.1002/14651858.CD003558.pub2
Study Reason for exclusion
Adelroth 1998 Not an RCT but a review article.
Agertoft 1994 Not RCT (CCT) of 278 children with asthma. Intervention group with budesonide but control group consisted of SCG, theophylline, or B2‐agonists.
Anonymous 1975 Not an RCT but a case presentation.
Anonymous 1996 Not an RCT but a review paper.
Anonymous 1997 Review paper, not RCT.
Arner 1971 RCT ‐ asthmatic adults already on corticosteroids were randomized to SCG or placebo and then crossed over.
Balzano 2002 Not an RCT
Baxter Jones 2000 Comparison involved ssA2 agonist versus inhaled steroids.
Bisgaard 2004 may enroll patients without asthma
Brown 1973 Not an RCT. 31 children with asthma were placed on ICS.
Capristo 1994 Comparison involved nedocromil vs ICS rather than SCG vs ICS.
Carlsen 1996 Not an RCT but a review.
Carter 2002 Not an RCT
Chuchalin 2002 Comparison not ICS or SCG
Cockcroft 1987 Intervention too short. RCT involving 10 adults with asthma who received BDP, SCG, or salbutamol alone for 6 days and had assessment of FEV1.
Comis 1993 Comparison involved SCG vs. nedocromil rather than ICS, and outcomes related to exercise‐induced asthma (not an outcome of interest).
Del Bufalo 1993 Comparison involved nedocromil vs placebo rather than ICS vs SCG in patients with COPD and not asthma.
Donahue 1997 Not an RCT (a cohort study).
Dubus 2003 Not an RCT
Friday 1973 Comparison involved SCG vs placebo in steroid‐dependent asthmatics.
Gordon 2003 Comparison not ICS vs. SCG
Higgs 1996 Intervention length of 2 weeks was too short.
Holgate 1997 Not an RCT but an editorial.
Kannisto S 2000 Not RCT (CCT involving 75 children with asthma. 60 were randomized to BUD or FP and remaining 15 were placed on SCG or nedocromil).
Kanter 1997 Not RCT(This should be listed as review paper.)
Khurana 1977 Not RCT. Cohort study of 70 children treated with cromolyn and followed prospectively for 5 years.
Kidner 1968 Not direct comparison (RCT of 28 asthmatic patients randomized to SCG or placebo).
Kurokawa 1970 Comparison of Intal (SCG) vs placebo rather than SCG vs ICS.
Lindquist 2001 Not RCT
Mapp 1987 Short washout period (1 week), short intervention (1 week), outcome not pertinent.
Martinati 1996 Not RCT (CCT) of 64 children with asthma ages 5‐10.
Martinati 1998 Not RCT (cohort study) of 49 children with asthma.
Mathison 1971 RCT of cromolyn vs placebo in 30 adults with asthma. Inhaled steroids in both groups.
Meyer 2003 Comparison not of SCG or ICS
Muijsers 2002 not an RCT
Nikander 2003 Comparison not of SCG or ICS
Pauwels 2003 Comparison not of SCG vs. ICS
Pelikan 1988a No outcomes of interest (bronchial provocation tests); too short intervention (1 day).
Pelikan 1988b Not an RCT, no outcomes of interest. 61 patients with asthma were pretreated with DSCG or BDP and measured late asthmatic responses.
Pepys 1974 Not RCT (8 adults with asthma were given SCG and BDP on successive days), no outcome of interest (immediate and late asthma reactions), too short intervention (1 day).
Petersen 1996 Not a direct comparison of SCG vs ICS. Children on ICS were randomized to SCG or placebo and outcomes were measured.
Pichaipat 1995 Not RCT (14 children with asthma were given placebo, terbutaline, SCG, or budesonide on successive weeks); no outcomes of interest (exercise induced fall in FEV1).
Reijonen 1996 No subjects with asthma (children 1 to 23 months old with bronchiolitis).
Reijonen 1998 No subjects with asthma (children 1 to 23 months old with bronchiolitis were enrolled).
Rubinfeld 1985 An RCT, but comparison was nedocromil vs. placebo.
Ruffin 1987 An RCT, but comparison was nedocromil vs. placebo.
Sarsfield 1977 Not RCT
Shore 1971 Not an RCT (all 90 children with asthma were given SCG); no controls; no inhaled steroid arm.
Sidelnikov 1985 Not an RCT.
Sin Hyung 1998 Involved children with exercise‐induced asthma rather than chronic asthma. Intervention was only 1 day rather than minimum of 4 weeks.
Toogood 1981 Comparison of ICS +/‐ SCG
Volovitz 2003 Comparison not SCG or ICS
Von Berg 2002 comparison not of SCG or ICS
Wuthrich 1982 Too short intervention (10 days) and washout (4 days). Cross‐over RCT of 36 asthmatics comparing SCG with FCB.
Zeiger 1991 not an RCT