| Adelroth 1998 |
Not an RCT but a review article. |
| Agertoft 1994 |
Not RCT (CCT) of 278 children with asthma. Intervention group with budesonide but control group consisted of SCG, theophylline, or B2‐agonists. |
| Anonymous 1975 |
Not an RCT but a case presentation. |
| Anonymous 1996 |
Not an RCT but a review paper. |
| Anonymous 1997 |
Review paper, not RCT. |
| Arner 1971 |
RCT ‐ asthmatic adults already on corticosteroids were randomized to SCG or placebo and then crossed over. |
| Balzano 2002 |
Not an RCT |
| Baxter Jones 2000 |
Comparison involved ssA2 agonist versus inhaled steroids. |
| Bisgaard 2004 |
may enroll patients without asthma |
| Brown 1973 |
Not an RCT. 31 children with asthma were placed on ICS. |
| Capristo 1994 |
Comparison involved nedocromil vs ICS rather than SCG vs ICS. |
| Carlsen 1996 |
Not an RCT but a review. |
| Carter 2002 |
Not an RCT |
| Chuchalin 2002 |
Comparison not ICS or SCG |
| Cockcroft 1987 |
Intervention too short. RCT involving 10 adults with asthma who received BDP, SCG, or salbutamol alone for 6 days and had assessment of FEV1. |
| Comis 1993 |
Comparison involved SCG vs. nedocromil rather than ICS, and outcomes related to exercise‐induced asthma (not an outcome of interest). |
| Del Bufalo 1993 |
Comparison involved nedocromil vs placebo rather than ICS vs SCG in patients with COPD and not asthma. |
| Donahue 1997 |
Not an RCT (a cohort study). |
| Dubus 2003 |
Not an RCT |
| Friday 1973 |
Comparison involved SCG vs placebo in steroid‐dependent asthmatics. |
| Gordon 2003 |
Comparison not ICS vs. SCG |
| Higgs 1996 |
Intervention length of 2 weeks was too short. |
| Holgate 1997 |
Not an RCT but an editorial. |
| Kannisto S 2000 |
Not RCT (CCT involving 75 children with asthma. 60 were randomized to BUD or FP and remaining 15 were placed on SCG or nedocromil). |
| Kanter 1997 |
Not RCT(This should be listed as review paper.) |
| Khurana 1977 |
Not RCT. Cohort study of 70 children treated with cromolyn and followed prospectively for 5 years. |
| Kidner 1968 |
Not direct comparison (RCT of 28 asthmatic patients randomized to SCG or placebo). |
| Kurokawa 1970 |
Comparison of Intal (SCG) vs placebo rather than SCG vs ICS. |
| Lindquist 2001 |
Not RCT |
| Mapp 1987 |
Short washout period (1 week), short intervention (1 week), outcome not pertinent. |
| Martinati 1996 |
Not RCT (CCT) of 64 children with asthma ages 5‐10. |
| Martinati 1998 |
Not RCT (cohort study) of 49 children with asthma. |
| Mathison 1971 |
RCT of cromolyn vs placebo in 30 adults with asthma. Inhaled steroids in both groups. |
| Meyer 2003 |
Comparison not of SCG or ICS |
| Muijsers 2002 |
not an RCT |
| Nikander 2003 |
Comparison not of SCG or ICS |
| Pauwels 2003 |
Comparison not of SCG vs. ICS |
| Pelikan 1988a |
No outcomes of interest (bronchial provocation tests); too short intervention (1 day). |
| Pelikan 1988b |
Not an RCT, no outcomes of interest. 61 patients with asthma were pretreated with DSCG or BDP and measured late asthmatic responses. |
| Pepys 1974 |
Not RCT (8 adults with asthma were given SCG and BDP on successive days), no outcome of interest (immediate and late asthma reactions), too short intervention (1 day). |
| Petersen 1996 |
Not a direct comparison of SCG vs ICS. Children on ICS were randomized to SCG or placebo and outcomes were measured. |
| Pichaipat 1995 |
Not RCT (14 children with asthma were given placebo, terbutaline, SCG, or budesonide on successive weeks); no outcomes of interest (exercise induced fall in FEV1). |
| Reijonen 1996 |
No subjects with asthma (children 1 to 23 months old with bronchiolitis). |
| Reijonen 1998 |
No subjects with asthma (children 1 to 23 months old with bronchiolitis were enrolled). |
| Rubinfeld 1985 |
An RCT, but comparison was nedocromil vs. placebo. |
| Ruffin 1987 |
An RCT, but comparison was nedocromil vs. placebo. |
| Sarsfield 1977 |
Not RCT |
| Shore 1971 |
Not an RCT (all 90 children with asthma were given SCG); no controls; no inhaled steroid arm. |
| Sidelnikov 1985 |
Not an RCT. |
| Sin Hyung 1998 |
Involved children with exercise‐induced asthma rather than chronic asthma. Intervention was only 1 day rather than minimum of 4 weeks. |
| Toogood 1981 |
Comparison of ICS +/‐ SCG |
| Volovitz 2003 |
Comparison not SCG or ICS |
| Von Berg 2002 |
comparison not of SCG or ICS |
| Wuthrich 1982 |
Too short intervention (10 days) and washout (4 days). Cross‐over RCT of 36 asthmatics comparing SCG with FCB. |
| Zeiger 1991 |
not an RCT |