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. 2020 Jan 29;40(5):1133–1144. doi: 10.1523/JNEUROSCI.1333-19.2019

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Copyright © 2020 Fan et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 6. — Increased survival times and synaptic densities in Tg-CX3CL1/PS19 mice. A, B, PS19 mice were not able to survival beyond 12 months, and this survival time was significantly increased by overexpression of CX3CL1 in Tg-CX3CL1/PS19 mice. However, Few of the Tg-CX3CL1/PS19 mice lived to 18 months of age, as reflected in the Kaplan–Meier curve (N = 14 in the Tg-CX3CL1/PS19 mice in the Tg-CX3CL1/PS19 mice group; ***p < 0.001, Student's t test). Both WT and Tg-CX3CL1 mice have normal life spans and easily live beyond 2 years of age. C, Confocal staining was performed to examine synaptic density labeled by synaptophysin in the hippocampus, and PS19 mice showed severely reduced synaptic density. Scale bar, 30 μm.