Table 1 –
Opioid allergy reactions
| Reaction | Freq.* | % | Likely immunemediated | Potentially life threatening |
|---|---|---|---|---|
| Hives or Rash | 75,528 | 20.8 | Yes | No |
| Gastrointestinal Upset | 63,583 | 17.5 | No | No |
| Itching | 32,291 | 8.9 | No | No |
| Mental Status Change | 22,669 | 6.2 | No | No |
| Vomiting | 22,555 | 6.2 | No | No |
| Nausea | 21,820 | 6.0 | No | No |
| Anaphylaxis | 15,953 | 4.4 | Yes | Yes |
| Shortness of Breath | 5,175 | 1.4 | Yes | Yes |
| Swelling (unspecified location) | 4,725 | 1.3 | Yes | No |
| Headaches | 4,342 | 1.2 | No | No |
| Angioedema | 3,269 | 0.9 | Yes | Yes |
| Hypotension | 2,785 | 0.8 | Yes | No |
| Bronchospasm or Wheezing | 2,428 | 0.7 | Yes | Yes |
| Seizures | 1,829 | 0.5 | No | Yes |
| Unknown/ unavailable |
76,861 | 21.1 | n/a | n/a |
| Total | 363,557 | 147,780 | 37,678 |
*
The total frequency of allergic reactions is larger than unique DAI alerts triggered since each unique DAI alert could have more than one associated reactions.