Figure 3:

NMR structures of lasso peptides identified by genome mining. LP 2006 (PDB 5JPL) and sviceucin (PDB 2LS1) are buttressed by disulfide bonds (yellow). Klebsidin (PDB 5UI7), acinetodin (5UI6) and citrocin (6MW6) are all RNA polymerase inhibitors. Benenodin-1 establishes a thermodynamic equilibrium between 2 distinct threaded conformers (PDB 5TJ1 and 6B5W). Subterisin was isolated from Sphingomonas (PDB 5XM4) and sphaericin was isolated from an actinobacterium and is antimicrobial (PDB 5GVO).