Skip to main content
. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: FEBS Lett. 2019 Aug 21;593(17):2488–2500. doi: 10.1002/1873-3468.13574

Figure 3: Yeast TRAPP complexes in secretion and autophagy. Whereas the structure of TRAPP complexes is known, their functions are still controversial.

Figure 3:

Core TRAPP, or TRAPP I, contains four different subunits: Bet3 (two copies, 3a and 3b), Bet5, Trs23, and Trs31. These subunits are common to all other TRAPP complexes. Trs20 (orange) is an adaptor required for assembly of two large TRAPP complexes: TRAPP II, contains three TRAPP II-specific subunits (grey), Trs120, Trs130 and Trs65 or Trs33; TRAPP III contains one TRAPP III-specific subunit, Trs85 (green). TRAPP IV contains Trs33. We propose that while TRAPP I and II regulate early and late steps in the secretory pathway, TRAPP III and IV regulate autophagy [16]. However, the uncertainties concerning the roles of TRAPP I and TRAPP III in secretion and of TRAPP II in PM recycling are indicated by question marks (?). Subunit diagram depicts relative size of the subunits and is modeled based on complexes structure or architecture (TrsX, X is roughly the size of the subunit in Kd). In the shown orientation, Ypt1 interacts with Bet5 and Trs23 on the bottom surface [53].