. Author manuscript; available in PMC: 2020 Sep 1.

Published in final edited form as: FEBS Lett. 2019 Aug 21;593(17):2488–2500. doi: 10.1002/1873-3468.13574

Table 2:

TRAPP complexes subunits

TRAPP Complex	Yeast Subunit	Yeast Viability	Human Subunit	Human Viability ^a	Identity (%) ^b
Core / I	Bet3	Essential	TRAPPC3	Essential	50
	Bet5	Essential	TRAPPC1	Essential	27
	Trs23	Essential	TRAPPC4	Essential	26
	Trs31	Essential	TRAPPC5	Essential	19
Adaptor (II & III)	Trs20	Essential	TRAPPC2	Non-essential ^c	32
II	Trs120	Essential	TRAPPC9	Non-essential	14
	Trs130	Essential	TRAPPC10	Non-essential	13
	Trs65	Non-essential	TRAPPC13	Non-essential	12
III	Trs85	Non-essential	TRAPPC8	Essential	8–18 ^d
IV	Trs33	Non-essential	TRAPPC6A/B	Non-essential ^e	16/19
			TRAPPC11	Essential	NA
			TRAPPC12	Non-essential	NA

Essentiality for human cell viability [16]

Identity in amino acids sequence between yeast and human subunits (Align, UniProt)

TRAPPC2 has a paralog, TRAPPC2L (20% identity)

18% identity considering that Trs85 has 698 amino acids compared to 1435 of TRAPPC8

TRAPPC6 A and B share 56% identity; their combined essentiality was not reported