TABLE 2.

Contribution of MET to KEGG metabolic pathways

Pathway	No. of novel orthologies by condition and speciesa
	All	MET						Abx-MET
	A. intestini	E. eligens	B. ovatus	E. ventriosum	P. distasonis	R. faecis	R. inulinivorans	E. fissicatena	C. comes	F. plautii
Amino sugar and nucleotide sugar metabolism		+		+		++	+			+
Arginine and proline metabolism		+	+		++	+	+	+		+
Butanoate metabolism	+			++++				++		+++
d-Arginine and d-ornithine metabolism										++++
Fructose and mannose metabolism			+							+
Galactose metabolism					+	+		++	+
Glycerophospholipid metabolism		+		+	+		+	+	+	+
Lysine degradation										++++++
Methane metabolism				++++				+++		+
Propanoate metabolism				++++				++
Riboflavin metabolism			+							++
Starch and sucrose metabolism		+		+	+	+++	++	++	++
Sulfur metabolism		++				++

^aData represent the top three KEGG metabolic pathways that were attributed to each engrafted species from the healthy consortium of microbes (MET) into the ulcerative colitis-associated microbial community with and without rifaximin pretreatment (Abx), as determined by the number of KEGG orthologies contributed by each allochthonous species that were novel to the ulcerative colitis-associated microbial community present in the bioreactors. Each of these novel KEGG orthologies is represented by a + symbol, so that the number of novel KEGG orthologies per KEGG metabolic pathway may be observed. Species represented are the following: Acidaminococcus intestini, Eubacterium eligens, Bacteroides ovatus, Eubacterium ventriosum, Parabacteroides distasonis, Roseburia faecis, Roseburia inulinivorans, Eubacterium fissicatena, Coprococcus comes, and Flavonifractor plautii.