Table 7. Endpoint with lower BMD10 value (Non-neoplastic effects).
| Endpoint | Animal species (M/ F) *1 |
Model | Restrict | P-value | BMD10 mg/kg bw/day |
BMDL10 mg/kg bw/day |
BMDL10 /BMD10 |
BMDL10 /lowest dose |
Source |
|---|---|---|---|---|---|---|---|---|---|
| Overian atrophy | Rats (F) |
Log-Logistic | ON | 0.63 | 0.30 | 0.08 | 0.3 | 0.2 | NTP 2012 |
| Axonal degeneration of sciatic nerves | Rats (M) |
Quantal-Linear | *2 | 0.64 | 0.61 | 0.43 | 0.7 | 1.3 | NTP 2012 |
| Retinal degeneration | Rats (F) |
Log-Logistic | ON | 0.90 | 1.02 | 0.49 | 0.5 | 1.1 | NTP 2012 |
| Prepuce thymus pipe expansion | Rats (M) |
Log-Logistic | ON | 0.15 | 1.23 | 0.60 | 0.5 | 1.8 | NTP 2012 |
| Mouth vagina mucous membrane epithelium hyperplasia | Rats (M) |
Log-Logistic | ON | 0.45 | 2.08 | 1.07 | 0.5 | 107.1 | Johnson et al. 1986 |
※1) M: male; F: female ※2) Restrict option is not provided in the Quantal-Linear model.