Table 8. Endpoint with lower BMD10 value (Neoplastic effects).
| Endpoint | Animal
species (M/F) *1 |
Model | Restrict | P-value | BMD10 mg/kg bw/day |
BMDL10 mg/kg bw/day |
BMDL10 /BMD10 |
BMDL10 /lowest dose |
Sources |
|---|---|---|---|---|---|---|---|---|---|
| Clitoral gland adenoma | Rats (F) |
Log-Logistic | ON | 0.24 | 0.02 | 0.002 | 0.1 | 0.2 | Johnson et al. 1986 |
| Hardarian adenoma | Mice (M) |
Log-Logistic | ON | 0.34 | 0.36 | 0.17 | 0.5 | 0.2 | NTP 2012 |
| Hardarian adenoma/ adenocarcinoma | Mice (M) |
Log-Logistic | ON | 0.30 | 0.37 | 0.17 | 0.5 | 0.2 | NTP 2012 |
| Hardarian adenoma | Mice (F) |
Log-Logistic | ON | 0.43 | 0.47 | 0.28 | 0.6 | 0.3 | NTP 2012 |
| Mammary fibroadenoma | Rats (F) |
Log-Logistic | ON | 0.61 | 0.55 | 0.30 | 0.5 | 0.7 | NTP 2012 |
※1) M: male; F: female