Table 3. Distribution in tissues .
Dose (mg/kg bw) |
Hours after
administration (hrsa) |
Sex | Organ (μg/g) |
---|---|---|---|
1 | 72 | Male | Bone (0.123), Gastro-intestinal tract (0.031), Kidney (0.020), Carcassb (0.016), Liver (0.012), Others (0.010>) |
Female | Bone (0.112), Gastro-intestinal tract (0.075), Carcass (0.024), Skin (0.014), Liver (0.012), Kidney (0.012), Others (0.010>) | ||
10 | 72 | Male | Bone (0.511), Gastro-intestinal tract (0.152), Kidney (0.068), Carcass (0.062), Liver (0.059), Others (0.05>) |
Female | Bone (0.395), Gastro-intestinal tract (0.152), Carcass (0.056), Kidney (0.049) Liver (0.044), Others (0.03>) | ||
168 | Male | Bone (0.552), Carcass (0.106), Others (0.05>) | |
Female | Bone (0.313), Carcass (0.087), Others (0.05>) | ||
Male | Bone(0.47), Bone marrow(0.044),
Kidney(0.035), Carcass (0.034), Gastro-intestinal tract (0.030), Others (0.03>) |
||
Female | Bone (0.58), Bone marrow (0.093), Gastro-intestinal tract (0.032), Carcass (0.028), Lymph node (0.028), Others (0.025>) | ||
25 | 120 | Male | Bone (1.29), Large intestine (0.555), Carcass (0.294), Liver (0.216), Small intestine (0.206), Kidney (0.202), Others (0.2>) |
Female | Bone (2.31), Stomach (0.796), Liver
(0.333), Kidney (0.320), Urinary bladder (0.282), Lung (0.234), Small intestine (0.221), Carcass (0.201), Others (0.2>) |
||
100 | 168 | Male | Liver (0.518), Kidney (0.483), Stomach (0.424), Others (0.4>) |
Female | Stomach (0.600), Kidney (0.440), Liver (0.416), Others (0.4>) |
a, After single oral administration; b, Remaining without organs/tissues.