Table 2. Potential adverse effects of a single oral administration of folpet (Women who are or may be pregnant) .
| Species | Study | Dose (mg/kg bw/day) |
NOAEL (mg/kg bw/day) and critical endpoints1) |
|---|---|---|---|
| Rabbit | Developmental toxicity study (the 1st study) |
0, 10, 40, 160 | Maternal: 40 Maternal: Increased postimplantation loss rate |
| Developmental toxicity study (the 2nd study) |
0, 10, 20, 60 | Embryo/fetus: 10 Embryo/fetus: Hydrocephalus |
|
| ARfD | NOAEL: 10 SF: 100 ARfD: 0.1 |
||
| The critical study for setting ARfD | Developmental toxicity study in rabbits (the 2nd study) | ||
ARfD, Acute reference dose; SF, Safety factor 1) The adverse effect observed at LOAEL