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. 2018 Mar 30;6(1):7–32. doi: 10.14252/foodsafetyfscj.2017024

Fig. 9.

Fig. 9

Proposed biosynthesis of dityrptophenaline. The NRPS DtpA forms the diketopiperazine cyclo(L-Phe-L-Trp) from phenylalanine and tryptophan. DtpB methylates cyclo(L-Phe-L-Trp) and the P450 DtpC catalyzes dimerization affording ditryptophenaline. Adapted from Saruwatari et al.157).