Table 1. Description of PK parameters of WinNonlin® and the R packages.

Parameter	WinNonlin®	Description
b0	b0	Intercept
CMAX	Cmax	Max Concentration (Conc)
CMAXD	Cmax_D	Max Conc Norm by Dose
TMAX	Tmax_D	Time of Cmax
TLAG	Tlag	Time Until First Nonzero Conc
CLST	Clast	Last Nonzero Conc
CLSTP	Clast_pred	Last Nonzero Conc Pred
TLST	Tlast	Time of Last Nonzero Conc
LAMZHL	HL_Lambda_z	Half-Life Lambda z
LAMZ	Lambda_z	Lambda z
LAMZLL	Lambda_z lower	Lambda z Lower Limit
LAMZUL	Lambda_z upper	Lambda z Upper Limit
LAMZNPT	No_points_Lambda_z	Number of Points for Lambda z
CORRXY	Corr_XY	Correlation Between Time X and Log Conc Y
R2	Rsq	R Squared
R2ADJ	Rsq_adjusted	R Squared Adjusted
AUCLST	AUClast	AUC to Last Nonzero Conc
AUCALL	AUCall	AUC All
AUCIFO	AUCINF_obs	AUC Infinity Obs
AUCIFOD	AUCINF_D_obs	AUC Infinity Obs Norm by Dose
AUCIFP	AUCINF_Pred	AUC Infinity Pred
AUCIFPD	AUCINF_D_pred	AUC Infinity Pred Norm by Dose
AUCPEO	AUC_Extrap_obs	AUC %Extrapolation Obs
AUCPEP	AUC_Extrap_pred	AUC %Extrapolation Pred
AUMCLST	AUMClast	AUMC to Last Nonzero Conc
AUMCIFO	AUMCINF_obs	AUMC Infinity Obs
AUMCIFP	AUMCINF_pred	AUMC Infinity Pred
AUMCPEO	AUMC_Extrap_obs	AUMC %Extrapolation Obs
AUMCPEP	AUMC_Extrap_pred	AUMC % Extrapolation Pred
VZFO	Vz_F_obs	Vz Obs by F
VZFP	Vz_F_p	Vz Pred by F
CLFO	Cl_F_obs	Total CL Obs by F
CLFP	Cl_F_pred	Total CL Pred by F
MRTEVLST	MRTlast	MRT Extravasc to Last Nonzero Conc
MRTEVIFO	MRTINF_obs	MRT Extravasc Infinity Obs
MRTEVIFP	MRTINF_pred	MRT Extravasc Infinity Pred