Table 3. Geometric least-square means and geometric least-square mean ratios with 90% confidence intervals of the pharmacokinetic parameters of solifenacin for the two formulations.
Parameter | Geometric least-square mean | Geometric least-square mean ratio (Test/Reference) | ||
---|---|---|---|---|
Test (N=33) | Reference (N=33) | Point estimate | 90% confidence intervals | |
AUClast (h·ng/mL) | 470.48 | 453.42 | 1.0376 | 0.9702 – 1.1097 |
Cmax (ng/mL) | 14.23 | 13.72 | 1.0369 | 0.9779 – 1.0993 |
Notes: Test=solifenacin tartrate 10.66 mg; Reference=solifenacin succinate 10 mg
AUClast, area under the plasma concentration-time curve to the last sampling time; Cmax, maximum plasma concentration.