Table 3.

Multivariate Cox proportional regression analyses of predictive value of the BUN/Cr ratio on all‐cause mortality in the total acute decompensated heart failure population and the subcategories divided according to degree of ΔHgb

Hazard ratio of BUN/Cr ratio on all‐cause mortality in multivariate analysis
	Total		Extreme haemodilution		Modest haemodilution		Modest haemoconcentration		Extreme haemoconcentration
	HR [95% CI]	P value	HR [95% CI]	P value	HR [95% CI]	P value	HR [95% CI]	P value	HR [95% CI]	P value
Model 1	1.018 [1.006–1.023]	0.0018*	1.021 [1.003–1.039]	0.0224*	1.015 [0.994–1.034]	0.1509	NA [NA]	NA	1.021 [1.007–1.032]	0.0067*
Model 2	1.015 [1.005–1.023]	0.0023*	1.024 [1.004–1.042]	0.0140*	1.016 [0.994–1.036]	0.1323	NA [NA]	NA	1.021 [1.007–1.032]	0.0067*

In Model 1, in addition to the BUN/Cr ratio at discharge, we included established prognostic factors for acute decompensated heart failure including age, left ventricular ejection fraction at discharge, and treatment with angiotensin‐converting enzyme inhibitors or angiotensin receptor blockers, loop diuretics, and beta‐blockers at discharge. In Model 2, the independent variables that were significantly associated with all‐cause mortality in the univariate analyses, such as the presence of an ischaemic aetiology, systolic blood pressure, and resting heart rate, were included in the model, in addition to the aforementioned established predictive factors. BUN, blood urea nitrogen; CI, confidence interval; Cr, creatinine; HR, hazard ratio; NA, not available.

^* P < 0.05.