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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Clin Immunol. 2019 Oct 24;210:108270. doi: 10.1016/j.clim.2019.108270

Figure 1. X chromosome inactivation and X-linked immune genes.

Figure 1.

During development, in female cells, X-chromosome inactivation occurs randomly for one of the two X chromosomes, which equalizes the dosage of gene products from the X chromosome between females (XX) and males (XY). Each X chromosome has an equal probability of being silenced. Once established, inactivation of the X chromosome is stable, and perpetuates throughout subsequent division of the daughter cells. Through this process, each female is a mosaic of cells, composed of cells where either the maternally or paternally inherited X is expressed, and the other inherited X is silenced.