Table 1.
PCOS Traits in Humans Compared to the Prenatally Androgenized Monkey and Sheep Model
| PCOS TRAIT | HUMAN | PRENATALLY ANDROGENIZED RHESUS MONKEYS | PRENATALLY ANDROGENIZED FEMALE SHEEP | |
|---|---|---|---|---|
| EARLY TREATED | LATE TREATED | |||
| Reproductive | ||||
| Ovarian hyperandrogenism | Yes | Yes | Yes | Ovarian androgen receptor upregulation |
| Anovulation | Yes | Yes | Yes | Yes |
| Enlarged polyfollicular ovaries | Yes | Yes | Yes | Yes |
| LH hypersecretion | Yes | Yes | No | Yes |
| Reduced steroid negative feedback on LH | Yes | Yes | Yes | Yes |
| Impaired fertility | Yes | Yes | Yes | Yes |
| Metabolic | ||||
| Insulin resistance | Yes | Yes | No | Yes |
| Beta cell impairment | With increasing BMI | Yes | No | ? |
| Hyperglycemia | With increasing BMI | Yes | Yes | No |
| Increased type 2 diabetes | Yes | Yes | No | Unknown |
| Increased abdominal fat | Yes | Yes | With increasing BMI | ? |
| Hypertension | Yes | Unknown | Unknown | Yes |
| Dyslipidemia | Yes | Yes | Unknown | Yes |