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. 2020 Jan 23;7:371. doi: 10.3389/fcell.2019.00371

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Copyright © 2020 Peretti, Kim, Tufi and Lev.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The START proteins. Fifteen START proteins in human are grouped into six subfamilies. Three groups share the indicated lipid binding/transfer specificity of START domain, while the other three groups share the indicated functional domains. All members have their START domain at the C-terminal region. Among 15 START proteins, two of them, STARD3 and CERT, contain FFAT motif. STARD3, STARD10, STARD7, and STARD5 are found to be highly expressed and connected to poor prognosis in various cancers including breast cancer, gestational trophoblastic tumor (Clark, 2012). On the other hand, the expression of all members of Rho-GTPase subgroup, STARD8/12/13, STARD9, and STARD15 are reported to be decreased in cancer (Clark, 2012). The number at the right side of each C-terminal represents the length of each protein in amino acids.