Table 2.
Characteristics of cases and controls.
| Study ID | Case | Control |
|---|---|---|
| Kratz et al. (11) | From NCI Clinical Genetics Branch Familial Testicular Germ Cell Study (FTCS). | From the Prostate, Lung, Colorectal, Ovarian (PLCO) Cancer Screening Trial. |
| Marcotte et al. (12) | From the Children's Oncology Group Childhood Cancer Research Network (CCRN). | Parents of cases. |
| Rapley et al. (13) | From a UK study of familial testicular cancer and a national collection of TGCT Cases treated within the UK. Cases were recruited via the UK Testicular Cancer Collaboration (UKTCC). | From the 1958 Birth Cohort (1958BC). |
| Ruark et al. (14) | From a UK study of familial testicular cancer and a national collection of TGCT Cases treated within the UK. Cases were recruited via the UK Testicular Cancer Collaboration (UKTCC). | Controls for the GWAS: 2,482 from the 1958 Birth Cohort (1958BC) and 2,587 from the UK National Blood Service (NBS). Controls for the iCOGs replication: 814 age <65 male from a study of Prostate Cancer (UKGPCS), 7,871 controls (6,627 female and 1,244 male) from a SEARCH (Study of Epidemiology & Risk Factors in Cancer), 1,397 females from the BBCS (British Breast Cancer Study). |
| Litchfield et al. (15) | From a UK study of familial testicular cancer and a national collection of TGCT Cases treated within the UK. Cases were recruited via the UK Testicular Cancer Collaboration (UKTCC). | 2,976 male from the UK Genetic Prostate Cancer Study (UKGPCS) (age <65) and SEARCH (Study of Epidemiology & Risk Factors in Cancer), 4,446 female from Breast Cancer Association Consortium (BCAC). |
| Kristiansen et al. (16) | Recruitment of Norwegian TGCT patients diagnosed between 1990 and 2008 was based on data from the Cancer Registry of Norway. Recruitment of Swedish TGCT patients diagnosed between 1995 and 2006 was based on data from the Swedish National Cancer Registry. | From the TwinGene project, conducted between 2004 and 2008, is a population-based Swedish study of twins born between 1911 and 1958. |
| NCI (17, 18) | From NCI Clinical Genetics Branch Familial Testicular Germ Cell Study (FTCS) and US Servicemen's Testicular Tumor Environmental and Endocrine Determinants Study (STEED). | From the Prostate, Lung, Colorectal, Ovarian (PLCO) Cancer Screening Trial and STEED. |
| USC (19) | Individuals analyzed are part of a population-based study at the University of Southern California (USC) based in the California and the California Cancer Registry (CCR). | Controls from the NCI Breast & Prostate Cancer Cohort Consortium genome-wide study of aggressive prostate cancer. |
| Kanetsky et al. (20) | Most cases of discovery study were from the University of Pennsylvania (UPENN) Health System or Fox Chase Cancer Center. Cases of replication study were from western Washington State. | Controls of discovery study were from the University of Pennsylvania Catheterization Study (PennCATH). Controls of replication study were from western Washington State. |