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Endometriosis lesions are infiltrated by blood vessels, nerves, and macrophages. Lesion resident macrophages are derived from macrophages originating from the endometrium and recruited macrophages. Macrophages interact with blood vessels and nerves to stimulate their growth. Signaling also occurs between macrophages and stromal cells, which increases their clonal expansion and invasive properties. Created using Biorender.com.
