FIGURE 2.

Prolongation of δ sIPSC decay. In the presence of 50 μM PTX δ sIPSCs were isolated as described (Sun et al., 2018). (A) Scaled sIPSC waveforms from baseline and in the presence of 100 nM 3α5αP from 15 and 17 events, respectively. (B–D) In δ* KI DGCs (n = 7) decays were prolonged by 100 nM 3α5αP from 18.9 ± 2.3 ms to 26.1 ± 1.8 ms (paired t test, p = 0.01). Neither sIPSC amplitude (−9.1 ± 0.6 pA vs. −7.7 ± 0.7 pA) nor frequency (0.08 ± 0.006 Hz vs. 0.14 ± 0.04 Hz) was reliably altered (paired t test, p = 0.08, 0.2, respectively).