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Suspected mutant genes in immunostaining for MMR proteins
| Expression in immunostaining | ||||
|---|---|---|---|---|
| MLH1 | MSH2 | PMS2 | MSH6 | |
| Mutant gene | ||||
| MLH1 | − | + | − | + |
| MSH2 | + | − | + | − |
| PMS2 | + | + | − | + |
| MSH6 | + | + | + | − |
When staining results other than the patterns in the table are obtained, confirm the adequacy of staining before considering the possibility that the patient is exceptional and perform MSI testing if needed
