Table 2.
22 Published pediatric cases of PAAF, with or without DNA methylation profiling
| Authors | Institutional histopathological diagnosis | DNA methylation profile | Location | Age at diagnosis (years) | Gender [M: male; F: female] | Death | OS (months) | Progression | PFS (months) | Mitotic count/10HPFs | Necrosis | MAPK alteration | Homozygous CDKN2A deletion | Loss of ATRX | PIK3/ATK alteration | Other alterations |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Reinhardt 2018 | Anaplastic pilocytic astrocytoma | MC AAP | Posterior fossa | 0–18 | F | NA | NA | NA | NA | NA | NA | KIAA1549: BRAF | 1 | 1 | NA | 0 |
| Reinhardt 2018 | Anaplastic pilocytic astrocytoma | MC AAP | Spinal | 0–18 | F | NA | NA | NA | NA | NA | NA | FGFR1 mut/fus | 1 | 0 | NA | 0 |
| Reinhardt 2018 | Anaplastic pilocytic astrocytoma | MC AAP | Posterior fossa | 0–18 | M | NA | NA | NA | NA | NA | NA | FGFR1 mut/fus | 0 | 0 | NA | MGMT promoter methylation |
| Reinhardt 2018 | Anaplastic pilocytic astrocytoma | MC AAP | Posterior fossa | 0–18 | M | NA | NA | NA | NA | NA | NA | NOS | 1 | NA | NA | 0 |
| Reinhardt 2018 | Anaplastic pilocytic astrocytoma | MC AAP | Posterior fossa | 0–18 | M | NA | NA | NA | NA | NA | NA | NOS | 0 | 0 | NA | 0 |
| Reinhardt 2018 | Anaplastic pilocytic astrocytoma | MC AAP | Supratentorial | 0–18 | F | NA | NA | NA | NA | NA | NA | NOS | 0 | NA | NA | 0 |
| Lopéz 2018 | Anaplastic trans-formation of PA | NA | Cerebellum | 2 | F | NA | NA | 1 | 10 | 8 | 0 | NTRK2 | 1 | 0 | 0 | 0 |
| Rodriguez 2011 case 1 /2019 case 17 | Anaplastic pilocytic astrocytoma | NA | Cerebellum | 5 | M | A | NA | NA | NA | ≥ 4 | 0 | BRAF duplication | 0 | 0 | pAKT/pS6 IHC | |
| Rodriguez 2011 case 4/2019 case 25 | Anaplastic pilocytic astrocytoma | NA | R frontal lobe | 11 | M | A | NA | NA | NA | ≥ 4 | 1 | NEC | 0 | 0 | pAKT/pS6 IHC | |
| Rodriguez 2011 case 10/2019 case 22 | Anaplastic pilocytic astrocytoma | NA | 3rd ventricle | 10 | M | D | NA | NA | NA | ≥ 4 | 1 | NEC | 0 | 1 | pAKT/pS6 IHC | H3K27M |
| Rodriguez 2011 case 18 | Anaplastic pilocytic astrocytoma | NA | Spinal | 16 | M | NA | NA | NA | NA | ≥ 4 | 1 | NEC | NA | NA | PTEN het del + pAKT IHC | |
| Rodriguez 2011 case 24/2019 case 26 | Anaplastic pilocytic astrocytoma | NA | R occipital lobe | 11 | F | A | NA | NA | NA | ≥ 4 | 0 | NF1 | NA | 0 | pS6 IHC | |
| Rodriguez 2011 case 25/2019 case 27 | Anaplastic pilocytic astrocytoma | NA | Posterior fossa | 14 | M | D | NA | NA | NA | ≥ 4 | 1 | NOS | NA | 0 | NA | |
| Rodriguez 2019 case 1 | PA with anaplasia | NA | Cerebellum | 17 | M | D | NA | NA | NA | ≥ 5 | 1 | NEC | NA | 1 | 0 | |
| Rodriguez 2019 case 3 | PA with anaplasia | NA | Cerebellum | 13 | F | A | NA | NA | NA | ≥ 5 | 1 | NOS | NA | 1 | 0 | |
| Rodriguez 2019 case 4 | PA with anaplasia | NA | Cerebellum | 12 | F | D | NA | NA | NA | ≥ 5 | 1 | NF1 | NA | 0 | 0 | |
| Rodriguez 2019 case 11 | PA with anaplasia | NA | 3rd ventricle | 12 | M | A | NA | NA | NA | ≥ 5 | 1 | NEC | NA | 0 | 0 | |
| Rodriguez 2019 case 12 | PA with anaplasia | NA | L hemisphere | 3 | M | A | NA | NA | NA | ≥ 5 | 1 | NEC | NA | 0 | 0 | |
| Rodriguez 2019 case 13 | PA with anaplasia | NA | Posterior fossa | 4 | M | D | NA | NA | NA | ≥ 5 | 1 | KRAS | 0 | 1 | 0 | H3K27M |
| Olar 2019 | PAAF | NA | Cerebellum | 1.6 | M | A | 49 | 0 | 0 | ≥ 4 | 1 | KIAA1549: BRAF | NA | 1 | loss of PTEN/ pS6 + IHC | |
| Olar 2019 | PAAF | NA | Cerebellum, midline | 12 | F | A | 47 | 0 | 0 | ≥ 4 | 1 | NOS | NA | 1 | loss of PTEN/ pS6 + IHC | |
| Mistry 2015 | PA undergoing trans-formation | NA | Midline | > 5 | F | NA | NA | NA | NA | NA | NA | BRAF V600E | 1 | NA | NA |
A alive, D deceased, het del heterozygous deletion, IHC immunohistochemistry, MC AAP methylation class anaplastic astrocytoma with piloid features, NA not available, NEC not elsewhere classified, NOS not otherwise specified, PA pilocytic astrocytoma