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. 2020 Jan 29;10:1414. doi: 10.1038/s41598-020-58088-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Data flowchart based on a next-generation sequencing workflow. The objects shown in this diagram are classified into three class types- ‘Action’, ‘Information’, and ‘Entity’. ‘Action’ was first posted with respect to what occurred in each expert domain and the resulting ‘Information’ was displayed as a result of each action. Finally, ‘Entity’ was defined as the captured information class at each stage of the workflow. Subtypes of ‘Variant Information’ were drawn scalable to accommodate the potential extension of subclasses.