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. 2020 Jan 23;12:335. doi: 10.3389/fnmol.2019.00335

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Copyright © 2020 Gutierrez, Corey-Bloom, Thomas and Desplats.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Salivary BDNF levels according to sex and diagnostic group. BDNF levels in saliva (50 ul) were determined by ELISA. (A) No significant differences in BDNF were observed by sex (Student’s t test, unpaired; two-tailed). (B) BDNF levels are lower in premanifest (PM) and manifest HD (HD) cases when compared to normal controls (NC). ^∗p < 0.05; ^∗∗p < 0.01 in comparison to NC group as per One-way ANOVA. (C) BDNF levels are significantly lower in subjects who are >10 years from their predicted age of onset compared to those who are <10 years from predicted onset. ^∗p = 0.05. Predicted age to onset was calculated using the Langbehn formula (Langbehn et al., 2010). Data is shown as individual BDNF levels ± SD.