TABLE 4.

DNA methylation status at selected CpG sites from BDNF promoter IV.

CpG site	Genomic position Chr11	Methylation (%)1		p-value2
		NC	HD Gene (+)
436	27701529	1.2 (0.0 – 4.6)	1.3 (0.0 – 5.1)	0.89
437	27701549	4.1 (3.1 – 5.5)	2.9 (0.0 – 5.9)	0.032∗
438	27701579	1.0 (0.0 – 4.2)	1.0 (0.0 – 4.1)	0.849
439	27701582	3.9 (0.0 – 5.7)	3.1 (0.0 – 7.7)	0.196
440	27701591	2.4 (0.0 – 4.4)	2.3 (0.0 – 5.8)	0.889
441	27701597	1.5 (0.0 – 3.8)	1.7 (0.0 – 4.2)	0.706
444	27701644	1.1 (0.0 – 3.5)	2.3 (0.0 – 7.0)	0.028∗
445	27701657	0.9 (0.0 – 3.5)	2.1 (0.0 – 5.3)	0.023∗
446	27701668	0.3 (0.0 – 2.6)	1.4 (0.0 – 3.7)	0.002∗∗
447	27701672	2.9 (0.0 – 6.9)	2.9 (0.0 – 6.5)	0.961
448	27701691	5.3 (0.0 – 8.9)	6.4 (3.5 – 11.3)	0.079
449	27701699	3.2 (2.0 – 6.3)	3.7 (0.0 – 6.1)	0.312

¹Methylation levels are expressed as a mean percentage and (min–max) values. ²As per Student’s t test (unpaired; two-tailed). Significant differences are denoted by asterisks, ^∗ and ^∗∗, for the shown p-values.