Table 1.
Characteristics of the 4 Primary and 10 Additional MenB Test Strains.
| Strain | FHbp variant | Percentage identity to vaccine component | Strain MEASURE MFIa (±1 SD) | FHbp variant group MEASURE MFI medianb (±1 SD) | Clonal complex | Country of isolation |
|---|---|---|---|---|---|---|
| Primary Strains | ||||||
| PMB80 | A22 | 88.9 | 3127 (2440, 4007) | 2502 (1952, 3207) | CC41/44 | United States |
| PMB2001 | A56 | 98.1 | 5002 (3903, 6410) | 5002c | CC213 | France |
| PMB2948 | B24 | 86.2 | 6967 (5436, 8929) | 8457 (6599, 10,839) | CC32 | France |
| PMB2707 | B44 | 91.6 | 11,283 (8804, 14,461) | 14,753 (11,511, 18,907) | CC269 | United Kingdom |
| Additional Strains | ||||||
| PMB3010 | A06 | 96.2 | 3370 (2629, 4319) | 3088 (2410, 3958) | CC461 | United Kingdom |
| PMB3040 | A07 | 85.4 | 1379 (1076, 1767) | 1100 (858, 1409) | CC162 | Germany |
| PMB824 | A12 | 85.4 | 2540 (1982, 3255) | 2467 (1925, 3161) | CC35 | United States |
| PMB1672 | A15 | 85.1 | 2995 (2337, 3838) | 2904 (2266, 3721) | CC103 | France |
| PMB1989 | A19 | 88.1 | 1934 (1509, 2479) | 1759 (1372, 2254) | CC8 | United Kingdom |
| PMB3175 | A29 | 93.1 | 3839 (2995, 4920) | 5994 (4677, 7682) | CC32 | United States |
| PMB1256 | B03 | 90.8 | 3976 (3102, 5096) | 2935 (2290, 3762) | CC41/44 | United Kingdom |
| PMB866 | B09 | 88.1 | 2089 (1630, 2677) | 2275 (1775, 2916) | CC269 | United Kingdom |
| PMB431 | B15 | 86.5 | 3785 (2953, 4851) | 4822 (3763, 6180) | CC41/44 | United States |
| PMB648 | B16 | 86.2 | 2347 (1831, 3008) | 1996 (1557, 2558) | CC41/44 | United Kingdom |
FHbp factor H binding protein, MenB Neisseria meningitidis serogroup B, MFI mean fluorescence intensity, SBA serum bactericidal assay
aMFI ± 1 SD from MEASURE assay
bBased on the MenB SBA isolate collection (n = 1263), except for variant group A07, which was calculated from the extended MenB SBA isolate collection (n = 1814). Strains in each FHbp variant group with expression levels at or below median levels for the respective FHbp variant group were randomly selected. The cutoff level adopted for each FHbp variant group was the observed median MFI plus 1 SD, using the precision estimate of 25.2% relative SD
cThere is only one strain expressing A56; thus, no SD values are included