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. 2020 Jan 29;11(1):73. doi: 10.1038/s41419-020-2256-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Predicted VDR binding sites in human and mouse GPX4 gene promoter regions. Human and mouse GPX4 gene upstream regions were analyzed for VDR binding sites by JASPAR online analysis (http://jaspar.genereg.net). The potential binding sites of 90% chance (relative score) to bind VDR are listed. B Luciferase activity assay were conducted to assess the interaction between GPX4 gene promoter regions and transcription factor VDR in human 293 T cells. Luciferase reporter plasmid containing GPX4 promoter sequence (or blank sequence) were transinfected into the control 293 cells or VDR expressed cells, luciferase activity were quantitatively analyzed. The data are presented as the mean ± SD, *P < 0.05, **P < 0.01. n = 3.