Figure 2.

Binding modes of (A) 5-HT and (B) MTA to MAO-A (PDB: 2BXS). (C) Superimposed structures of 5-HT and MTA docked into the active site of MAO-A. (D) Superimposed binding sites of MAO-A (green residues) and MAO-B (orange residues) with MTA already docked into the active site of MAO-A; the “wrapper” around MTA represents the solvent accessible surface area (SASA). In all cases, for the sake of clarity, only the most relevant residues are shown. Docking conditions were as in Fierro et al., 2007.