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. 2020 Jan 23;10:1590. doi: 10.3389/fphar.2019.01590

Table 5.

MAO inhibitory activity of some AMPH derivatives containing aromatic systems larger than benzene.

graphic file with name fphar-10-01590-g015.jpg
MAOI Activity
IC50(Ki)a (µM)
Compoundb Ar MAO-A MAO-B
NIPA/PAL-287 graphic file with name fphar-10-01590-g016.jpg 0.42c > 100c
6-MeO-NIPA graphic file with name fphar-10-01590-g017.jpg 0.18c 16.3c
6-EtO-NIPA graphic file with name fphar-10-01590-g018.jpg 0.45c 13.6c
6-PrO-NIPA graphic file with name fphar-10-01590-g019.jpg 0.68c 13.5c
6-BuO-NIPA graphic file with name fphar-10-01590-g020.jpg 1.53c NT
6-MeS-NIPA graphic file with name fphar-10-01590-g021.jpg 0.50c NT
2-Benzofuryl-IPA graphic file with name fphar-10-01590-g022.jpg 0.80d > 100d
AMT graphic file with name fphar-10-01590-g023.jpg 0.38e > 10e
4-MeO-AMT graphic file with name fphar-10-01590-g024.jpg 1.4e > 10e
5-MeO-AMT graphic file with name fphar-10-01590-g025.jpg 31e > 10e
5-Me-AMT graphic file with name fphar-10-01590-g026.jpg 1.5e > 10e
5-F-AMT graphic file with name fphar-10-01590-g027.jpg 0.45e(0.032f) 376e(575f)
5-Cl-AMT graphic file with name fphar-10-01590-g028.jpg 0.25e 82e
7-Me-AMT graphic file with name fphar-10-01590-g029.jpg 0.049e > 10e

aIC50 and/or Ki are reported, depending on the reference considered. bChemical name and/or common acronym and/or common name is given. c Vilches-Herrera et al., 2009. d Vallejos et al., 2005. e Wagmann et al., 2017. f Kinemuchi et al., 1988. NT, Not tested. Ar, Aromatic ring. *: This symbol denotes where, in the aromatic ring, the aliphatic side chain is linked. Me, Methyl; Et, Ethyl; Pr, Propyl; Bu, Butyl.