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. 2020 Jan 23;9:1534. doi: 10.3389/fonc.2019.01534

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Copyright © 2020 Milazzo, Vesci, Anastasi, Chiapparino, Rosi, Giannini, Taddei, Cini, Faltoni, Petricci, Battistuzzi, Salvini, Carollo and De Santis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ST8176AA1 induces reversal of epithelial/mesenchymal transition in tumor cells. HCS imaging analysis showing that SKOV3 cells treated with ST8176AA1 exhibit increased expression of the claudin2 and E-cadherin (epithelial) proteins and reduction of vimentin and fibronectin (mesenchymal) proteins. ST8176AA1 and trastuzumab were used at 15 μg/mL (3 days incubation). In all panels, insets show specific fluorescence signals within the cells. Draq5 dye staining of nucleus (gray). Each image is representative of at least five fields of duplicate wells. Magnification 60X. Data are from one representative experiment out of two.