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. 2020 Jan 29;10:1451. doi: 10.1038/s41598-020-58323-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The protein isoforms OPN-a, OPN-b and OPN-c with corresponding exons. The short curly brackets show the sites of binding of the different antibodies for OPN-N and OPN-C, and the dark grey arrows show cleavage sites for MMPs and thrombin. The TaqMan-assay detects all transcripts as all transcript splice variants include exon 6 and 7 (long curly bracket).