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. 2020 Jan 29;10:1439. doi: 10.1038/s41598-020-58351-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Intra-tumoral immune heterogeneity in invasive urothalial carcinoma. Each row represents a patient and each column is a histologic variant. (a) Distribution of immune low and immune high cluster profile in different histologic variants from the same patient. (b) Distribution of PD-L1 scores in different histologic variants from the same patient. (c) Distribution of molecular subtypes in different histologic variants from the same patient. (d) Distribution of intra-tumoral CD3 scores in different histologic variants from the same patient.