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. 2020 Jan 23;10:1528. doi: 10.3389/fphar.2019.01528

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Copyright © 2020 Chen, Liu, Li, Han, Tang, Deng, Lai and Wan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dihydrotestosterone (DHT) regulates human hair follicles (HFs) growth through the Wnt/β-catenin pathway. HFs were cultured with IM12 (50, 100, or 500 nM), 21H7 (1, 2, or 4 µM), DHT (10^-6 mol/L), IM12 (500 nM), or 10^-6 mol/L DHT and 500 nM IM12. (A, B) Mean growth rates of hair shafts treated with IM12 and 21H7 (n = 10). (C) Mean growth rates of hair shafts treated with DHT and IM12 (n = 10). (D, E) Immunofluorescence staining and mean fluorescence intensity of β-catenin in HFs cultured with DHT and IM12 (n = 6). Magnification: 200× and 400×. The data are presented as the mean ± SD. Each bar represents the mean of three independent experiments performed in triplicate. Compared with the control (0 ) group, *P < 0.05 , ^&P < 0.05 and ^#P < 0.05. Scale bar 50 μm (200×).