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. 2020 Jan 29;10:1448. doi: 10.1038/s41598-020-57973-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TCDD exposure decreases % beta cell area and increases % delta cell area in male mice but does not affect islet cell composition in female mice. (A–D) Male and (E–H) female mice were injected with either corn oil or 20 μg/kg TCDD on day 0 and pancreas tissue was harvested on day 42 for analysis by immunofluorescence staining (see Fig. 2A for schematic timeline). (A,E) Average islet area. (B–D,F-H) % of islet area that is immunoreactive for insulin (B,F), glucagon (C,G), or somatostatin (D,H). (I–J) Representative images of pancreas sections from male and female mice exposed to either corn oil or TCDD showing immunofluorescence staining for insulin/glucagon or insulin/somatostatin. Scale bars = 50 μm. All data are presented as mean ± SEM. Individual data points on bar graphs represent biological replicates (different mice). **p<0.01 versus control; all data was analyzed by unpaired two-tailed t-test.