Table 1.
Patients characteristics according to subgroups. P-values were obtain with the Chi-square test.
| Patients - n° (%) | Overall | Low SMI | NON-Low SMI | p-value | Low SMD | NON-Low SMD | p-value |
|---|---|---|---|---|---|---|---|
| 100 | 50 | 50 | 51 | 49 | |||
| Age, years | |||||||
| Range | 25–88 | 27–88 | 36–86 | — | 40–86 | 27–88 | — |
| Median | 66 | 71 | 70 | 71 | 70 | ||
| Sex | |||||||
| Male | 67 (67) | 31 (62) | 36 (72) | — | 40 (78.4) | 27 (55.1) | — |
| Female | 33 (33) | 19 (38) | 14 (28) | 11 (21.6) | 22 (44.9) | ||
| Age (<70 ≥) | |||||||
| Non Elderly | 43 (43) | 19 (38) | 24 (48) | 0.315 | 21 (41.2) | 22 (44.9) | 0.7085 |
| Elderly | 57 (57) | 31 (62) | 26 (53) | 30 (58.8) | 27 (55.1) | ||
| ECOG PS | |||||||
| 0–1 | 59 (59) | 22 (44) | 37 (74) | 0.0324 | 28 (54.9) | 31 (63.3) | 0.3977 |
| ≥2 | 41 (41) | 28 (56) | 13 (26) | 23 (45.1) | 18 (36.7) | ||
| Primary tumor | |||||||
| NSCLC | 46 (46) | 22 (44) | 24 (48) | 0.5471 | 27 (52.9) | 19 (38.8) | 0.5549 |
| Melanoma | 27 (27) | 13 (26) | 14 (28) | 12 (23.5) | 15 (30.6) | ||
| Renal Cell Carcinoma | 15 (46) | 10 (20) | 5 (10) | 7 (13.7) | 8 (16.3) | ||
| Others | 12 (12) | 5 (10) | 7 (14) | 5 (9.8) | 7 (14.3) | ||
| No. of metastatic sites | |||||||
| ≤2 | 55 (55) | 26 (52) | 29 (58) | 0.5485 | 27 (52.9) | 28 (57.1) | 0.6744 |
| >2 | 45 (45) | 24 (48) | 21 (42) | 24 (47.1) | 21 (42.9) | ||
| Treatment Line | |||||||
| First | 30 (30) | 12 (24) | 18 (36) | 0.1927 | 14 (27.5) | 16 (32.7) | 0.5723 |
| Non-first | 70 (70) | 38 (76) | 32 (64) | 37 (72.5) | 33 (67.3) | ||
| Type of Immunotherapy | |||||||
| Anti-PD-1 | 91 (91) | 48 (96) | 43 (86) | — | 46 (90.2) | 45 (91.8) | — |
| Anti-PD-L1 | 9 (9) | 2 (4) | 7 (14) | 5 (9.8) | 4 (8.2) | ||
| BMI (kg/m2) | |||||||
| Median (range) | 25 (17.3–45.2) | 24 (16.4–39) | 27 (17.1–45) | — | 27 (18–45) | 24 (16.4–34) | — |
| Underweight (BMI ≤ 18.5), n°(%) | 5 (5) | 3 (6) | 2 (4) | 1 (2) | 4 (8.2) | ||
| Normal weight (BMI 18.5 < BMI ≤ 24.9), n°(%) | 41 (41) | 24 (48) | 17 (34) | 11 (21.6) | 30 (61.2) | ||
| Overweight (25 < BMI ≤ 29.9), n°(%) | 33 (33) | 17 (34) | 16 (32) | 23 (45.1) | 10 (20.4) | ||
| Obese (BMI ≥ 30), n° (%) | 21 (21) | 6 (12) | 15 (30) | 16 (31.3) | 5 (10.2) | ||
| SMI (cm2/m2) | |||||||
| Median | 48.2 | 42.7 | 56.5 | — | 49.5 | 45 | — |
| (range) | (28.2–95.2) | (28.2–56.8) | (36.9–95.9) | (28.2–85.8) | (32.8–95.9) | ||
| SMD (HU) | |||||||
| Median | 30.9 | 29.9 | 31.6 | — | 23.6 | 37.9 | — |
| (range) | (2.3–54.6) | (5.9–53.1) | (2.3–54.6) | (2.3–36.2) | (24.2–54.6) | ||