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. 2020 Jan 30;10:1847. doi: 10.1038/s41598-020-58751-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DAPT and RO4929097 effectively inhibit Notch signaling without altering cell viability. (A,B) Measurement of HUVEC (A) and hLEC (B) cell viability after GSI treatments. Quantitative data are represented as mean ± SEM. n = 3 for HUVEC and hLEC. Significance was determined by 2-tailed, type 2 Student’s t test, *P < 0.05. (C,D) Relative expression of downstream Notch target gene Hey1 in GSI-treated HUVEC (C) and hLEC (D). Quantitative data are represented as mean values of fold change over DMSO control ± SEM. n = 4 for each cell line. Gapdh and β-actin were used as housekeeping control. Significance was determined by 2-tailed, type 2 Student’s t test, *P < 0.05, **P < 0.01.