Table 2. Analysis of Association of SNPs gene models with ORR with/without consideration of potential confounders.
| Gene | Polymorphisms | Gene model | ORR | ORR | |||
|---|---|---|---|---|---|---|---|
| P-SV# | OR-SV# (95% CI) | P-MV* | OR-MV* (95% CI) | ||||
| CYP1A1 | rs1048943 (CYP1A1*2C) | DOM | 0.449 | 2.40 (0.248–23.181) | 0.229 | 5.223 (0.354–77.086) | |
| REC | 0.358 | 1.714 (0.543–5.410) | 0.813 | 1.201 (0.264–5.465) | |||
| rs2606345 | DOM | 0.168 | 2.963 (0.633–13.869) | 0.292 | 3.300 (0.358–30.398) | ||
| CYP1A2 | rs762551 | REC | 0.082 | 0.368 (0.120–1.134) | 0.048 | 0.196 (0.039–0.983) | |
| CYP3A4 | rs2242480 (CYP3A4*1G) | DOM | 0.330 | 0.294 (0.025–3.454) | 0.486 | 0.387 (0.027–5.589) | |
| REC | 0.722 | 0.822 (0.279–2.419) | 0.942 | 1.060 (0.220–5.101) | |||
| POR | rs1057868 (POR*37) | DOM | 0.273 | 2.588 (0.477–13.711) | 0.039 | 14.729 (1.146–189.37) | |
| REC | 0.336 | 0.547 (0.160–1.870) | 0.682 | 0.726 (0.158–3.347 | |||
| rs17685 (POR*11) | DOM | 0.594 | 1.607 (0.281–9.188) | 0.142 | 6.654 (0.529–83.747) | ||
| REC | 0.801 | 0.857 (0.258–2.844) | 0.873 | 1.126 (0.263–4.821) | |||
| UGT1A7 | rs6759892 | DOM | 0.468 | 0.667 (0.223–1.994) | 0.907 | 1.089 (0.261–4.551) | |
| ABCB1 | rs10256836 | REC | 0.847 | 1.118 (0.359–3.484) | 0.772 | 1.260 (0.263–6.029) | |
| rs1045642 | DOM | 0.298 | 0.425 (0.085–2.128) | 0.679 | 0.674 (0.104–4.383) | ||
| REC | 0.419 | 0.615 (0.190–1.995) | 0.187 | 0.277 (0.041–1.861) | |||
| rs1128503 | DOM | 0.778 | 1.167 (0.399–3.408) | 0.936 | 1.059 (0.263–4.254) | ||
| REC | 0.893 | 0.900 (0.193–4.194) | 0.782 | 1.346 (0.164–11.043) | |||
| rs2032582 | DOM | 0.068 | 0.219 (0.043–1.117) | 0.020 | 0.033 (0.002–0.585) | ||
| REC | 0.050 | 0.259 (0.067–1.000) | 0.136 | 0.286 (0.055–1.480) | |||
| ABCG2 | rs2231137 | DOM | 0.431 | 1.556 (0.518–4.669) | 0.399 | 1.764 (0.472–6.600) | |
| REC | 0.829 | 0.762 (0.065–8.943) | 0.742 | 1.757 (0.061–50.617) | |||
| rs2231142 | DOM | 0.968 | 0.978 (0.329–2.907) | 0.891 | 1.102 (0.275–4.411) | ||
| REC | 0.396 | 0.375 (0.039–3.605) | 0.546 | 0.376 (0.016–8.967) | |||
#, single variant logistic analysis for the contribution of the SNPs gene models for the ORR; *, adjusted P value by multivariate logistic regression analysis (Enter method) for potential clinical confounders, including gender, BSA, age, PS, smoking history, staging, pathology, EGFR status, treatment lines and platinum chemotherapy. SV, single variant logistic analysis; MV, multivariate logistic regression analysis; ORR, overall response rate; OR, odds ratio; 95% CI, 95% confidence interval; DOM, dominant model; REC, recessive model; SNPs, single nucleotide polymorphisms.