Table 4. Log-rank test for the association of SNPs gene models with PFS.
| Gene | Polymorphisms | Gene model | P | Median PFS (95% CI) |
|---|---|---|---|---|
| CYP1A1 | rs1048943 (CYP1A1*2C) | DOM | 0.656 | 16.23 (9.44–23.02) vs. 14.00 (6.41–21.59) |
| REC | 0.443 | 17.03 (10.68–23.29) vs. 14.0 (4.60–23.40) | ||
| rs2606345 | DOM | 0.868 | 16.23 (4.27–28.20) vs. 13.07 (6.90–19.24) | |
| CYP1A2 | rs762551 | REC | 0.926 | 13.53 (11.14–15.92) vs. 16.23 (8.50–23.97) |
| CYP3A4 | rs2242480 (CYP3A4*1G) | DOM | 0.002 | 14.00 (8.58–19.42) vs. 5.37 (1.63–9.10) |
| REC | 0.327 | 17.90 (14.91–20.89) vs. 10.33 (8.42–12.24) | ||
| POR | rs1057868 (POR*37) | DOM | 0.874 | 12.40 (5.98–18.82) vs. 14.00 (6.67–21.33) |
| REC | 0.253 | 11.53 (9.56–13.50) vs. 17.03 (12.05–22.02) | ||
| rs17685 (POR*11) | DOM | 0.423 | 12.40 (6.03–18.77) vs. 13.53 (0.36–26.71) | |
| REC | 0.181 | 11.53 (9.56–13.50) vs. 16.23 (11.25–21.22) | ||
| UGT1A7 | rs6759892 | DOM | 0.995 | 13.53 (8.52–18.55) vs. 14.00 (4.20–23.80) |
| ABCB1 | rs1045642 | REC | 0.797 | 12.40 (9.46–15.34) vs. 14.00 (8.12–19.88) |
| rs10256836 | REC | 0.040 | 17.40 (12.19–22.61) vs. 10.33 (7.58–13.09) | |
| rs1128503 | DOM | 0.721 | 16.23 (8.12–24.35) vs. 13.53 (7.51–19.56) | |
| REC | 0.975 | 10.97 (0–24.27) vs. 14.00 (7.67–20.33) | ||
| rs2032582 | DOM | 0.159 | 11.80 (6.86–16.74) vs. 17.03 (9.92–24.15) | |
| REC | 0.322 | 11.80 (8.47–15.13) vs. 18.73 (16.52–20.54) | ||
| ABCG2 | rs2231137 | DOM | 0.390 | 11.53 (8.22–4.85) vs. 17.50 (11.29–23.71) |
| REC | 0.652 | 8.23 (4.18–12.29) vs. 14.00 (7.94–20.06) | ||
| rs2231142 | DOM | 0.554 | 12.40 (8.47–16.33) vs. 16.23 (9.32–23.15) | |
| REC | 0.484 | 12.40 (7.96–16.84) vs. 13.53 (7.36–19.71) |
SNPs, single nucleotide polymorphisms; PFS, progression free survival; 95% CI, 95% confident interval; DOM, dominant model; REC, recessive model.