Table S1. Genotype frequency and Hardy-Weinberg equilibrium test for SNPs.

Gene	Rs	N	Genotype frequency			Minor allelic frequency	HWE P value
			wt/wt, n [%]	wt/m, n [%]	m/m, n [%]
CYP1A1	rs1048943 (CYP1A1*2C)	53	29 [54]	19 [37]	5 [9]	0.27	0.47
	rs2606345	58	50 [86]	7 [12]	1 [2]	0.08	0.23
CYP1A2	rs762551 (CYP1A2*1F)	56	26 [47]	26 [46]	4 [7]	0.30	0.46
CYP3A4	rs2242480 (CYP3A4*1G)	57	25 [45]	29 [50]	3 [5]	0.30	0.14
POR	rs1057868 (POR*37)	55	18 [33]	28 [51]	9 [16]	0.43	0.73
	rs17685 (POR*11)	53	17 [33]	29 [54]	7 [13]	0.40	0.32
UGT1A7	rs6759892	55	28 [52]	25 [45]	2 [3]	0.26	0.20
ABCB1	rs1045642	54	19 [35]	28 [53]	7 [12]	0.39	0.50
	rs10256836	58	39 [67]	18 [31]	1 [2]	0.17	0.49
	rs1128503	58	24 [42]	26 [44]	8 [14]	0.35	0.82
	rs2032582	56	12 [21]	32 [58]	12 [21]	0.50	0.28
ABCG2	rs2231137	56	25 [44]	27 [49]	4 [7]	0.32	0.36
	rs2231142	55	26 [46]	24 [45]	5 [9]	0.31	0.87

HWE, Hardy-Weinberg equilibrium.