Table 7. Correlation among mRNA m6A% and the mRNA expressions of m6A modulators.
Partial correlations | METTL3 | METTL14 | ALKBH | FTO | YTHDF1 | YTHDF2 | YTHDF3 | m6A (%) |
---|---|---|---|---|---|---|---|---|
METTL3 | ||||||||
Partial correlation coefficient | – | |||||||
P value | – | |||||||
METTL14 | ||||||||
Partial correlation coefficient | 0.694 | – | ||||||
P value | 0.000 | – | ||||||
ALKBH | ||||||||
Partial correlation coefficient | 0.205 | –0.084 | – | |||||
P value | 0.360 | 0.710 | – | |||||
FTO | ||||||||
Partial correlation coefficient | –0.338 | –0.288 | –0.191 | – | ||||
P value | 0.124 | 0.194 | 0.394 | – | ||||
YTHDF1 | ||||||||
Partial correlation coefficient | 0.959 | 0.672 | 0.138 | -0.395 | – | |||
P value | 0.000 | 0.001 | 0.539 | 0.068 | – | |||
YTHDF2 | ||||||||
Partial correlation coefficient | 0.927 | 0.679 | 0.433 | –0.297 | 0.840 | – | ||
P value | 0.000 | 0.001 | 0.044 | 0.179 | 0.000 | – | ||
YTHDF3 | ||||||||
Partial correlation coefficient | 0.960 | 0.793 | 0.062 | –0.296 | 0.905 | 0.913 | – | |
P value | 0.000 | 0.000 | 0.785 | 0.181 | 0.000 | 0.000 | – | |
m6A (%) | ||||||||
Partial correlation coefficient | 0.483 | 0.489 | –0.119 | –0.150 | 0.541 | 0.479 | 0.559 | – |
P value | 0.023 | 0.021 | 0.597 | 0.504 | 0.009 | 0.024 | 0.007 | – |
Controlled with age, gender, and smoking. mRNA, messenger RNA; m6A, N6-methyladenosine.