Table 2. Significant GO term of DE genes in T lymphocytes related biological process.

GO:ID	Term, regulation in sepsis with hypoxic vs. non-hypoxic	Count	Fold. Enrichment	P value	Genes (117 genes in total)
GO:0033081	Regulation of T cell differentiation in thymus, down	5	2.76	0.030	FOXJ1//SHH//TESPA1//FOXN1//CLPTM1
GO:0042110	T cell activation, up	77	1.34	0.004	BAX//IL15//LCP1//PSEN1//CLEC4E//CLEC4D//RHOA//PTPN22//RHOH//PTPN2//SP3//VAV1//RUNX2//TNFSF13B//CTLA4//GRB2//CD274//LYN//PAK2//PDPK1//PIK3CA//PTPN6//RAC1//SRC//CDC42//RIPK3//CTNNB1//JMJD6//GLI3//LIG4//B2M//ADAM17//SOS1//PRDM1//BMP4//RIPK2//HLA-E//CTPS1//PIK3CG//CORO1A//ANXA1//CD46//NCK1//HAVCR2//PYCARD//IL18//HLA-G//PELI1//RAB27A//FCGR2B//CEACAM1//CYLD//IRF1//TNFSF8//ATG5//BATF//PRELID1//CBFB//HLX//NLRP3//PRKAR1A//MICB//FAM49B//BCL10//CD47//CD300A//ZBTB16//AP3B1//STAT3//GSN//DDOST//PPP3CA//AZI2//CLEC7A//TREML2//CASP8//HSH2D
GO:0030217	T cell differentiation, up	38	1.36	0.030	CLEC4E//CLEC4D//RHOA//RIPK3//CTNNB1//JMJD6//GLI3//LIG4//B2M//ADAM17//SOS1//PRDM1//BMP4//CYLD//IRF1//TNFSF8//CD46//ATG5//IL15//BATF//PRELID1//CTLA4//CBFB//HLA-G//ANXA1//HLX//RIPK2//NLRP3//IL18//ZBTB16//AP3B1//STAT3//PTPN2//PTPN22//RHOH//SP3//VAV1//RUNX2
GO:0050852	T cell receptor signaling pathway, up	50	2.01	7.9E-07	CD300A//BCL10//CYLD//PRKD2//ELF1//PTPN22//GBP1//PTPN2//PTPN6//CEACAM1//EZR//CHUK//DENND1B//LCP2//NCK1//NFKBIA//PAK2//PDE4B//PDPK1//PIK3CA//PIK3CB//PLCG2//PSEN1//PSMA1//PSMA2//PSMA3//PSMA4//PSMA5//PSMA6//PSMB1//PSMB3//PSMB4//PSMB6//PSMB7//PSMB8//PSMB9//PSMB10//PSMC1//PSMC2//PSMC6//PSMD11//PSMD12//PSMD13//PSME2//BTK//TEC//CUL1//RIPK2//THEMIS2//PSMD6
GO:0050856	Regulation of T cell receptor signaling pathway, up	11	2.46	0.003	CYLD//PRKD2//ELF1//PTPN22//GBP1//PTPN2//PTPN6//CEACAM1//EZR//CD300A//BCL10
GO:0050860	Negative regulation of T cell receptor signaling pathway, up	7	3.13	0.004	ELF1//PTPN22//GBP1//PTPN2//PTPN6//CEACAM1//EZR