Forest plots for comparisons of Δferritin. The heterogeneity was found in the meta-analysis of Δferritin (WMD =−51.31, 95% CI: −72.91 to −29.71, I2=63%, P<0.00001, A). After excluding Besarab et al.’s study, a significant decrease of Δferritin was shown (WMD =−61.05, 95% CI: −85.70 to −36.40, I2=44%, P<0.00001, B). In sensitivity analysis, Chen et al.’s (C) and Akizawa et al.’s (D) studies were confirmed not the origin of the heterogeneity. WMD, weighted mean difference.