Forest plots for comparisons of diarrhea, adverse events and severe adverse events. Our results of meta-analysis showed no significant difference in diarrhea occurrence (OR =1.54, 95% CI: 0.49 to 4.79, I2=0%, P=0.46, A), adverse events (OR =1.31, 95% CI: 0.76 to 2.27, I2=0%, P=0.34, B) and severe adverse events (OR =1.25, 95% CI: 0.29 to 5.35, I2=0%, P=0.76, C) in comparisons between the roxadustat and the placebo groups. OR, odds ratio.