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. 2019 Dec;7(23):792. doi: 10.21037/atm.2019.11.53

Table 4. Biomarker that predict treatment response.

Type Biomarker Treatment GOR
Metabolic Serum carnitine Carnitine C
Glutathione/methylation mB12 C
Pterin redox ratio BH4 *
Immune FRAA Leucovorin Ca C
Cunningham panel IVIG *
Autonomic RMSSD, pNN50 Propranolol C
Genetic CD38 rs3796863 SNP Oxytocin C
OXTR rs6791619 SNP Oxytocin C
Neuroimaging MRS/rsfMRI Riluzole C

*, not enough studies to make a recommendation because the only study is open-label. BH4, tetrahydrobiopterin; FA, folinic acid; FRAA, folate receptor alpha autoantibody; IVIG, intravenous immunoglobulin; mB12, methyl-B12; MRS, magnetic resonance spectroscopy; pNN50, proportion of successive R–R intervals differing by more than 50 ms; RMSSD, root mean square differences of adjacent R–R intervals; rsfMRI, resting state functional MRI.