Table 4. Biomarker that predict treatment response.
| Type | Biomarker | Treatment | GOR |
|---|---|---|---|
| Metabolic | Serum carnitine | Carnitine | C |
| Glutathione/methylation | mB12 | C | |
| Pterin redox ratio | BH4 | * | |
| Immune | FRAA | Leucovorin Ca | C |
| Cunningham panel | IVIG | * | |
| Autonomic | RMSSD, pNN50 | Propranolol | C |
| Genetic | CD38 rs3796863 SNP | Oxytocin | C |
| OXTR rs6791619 SNP | Oxytocin | C | |
| Neuroimaging | MRS/rsfMRI | Riluzole | C |
*, not enough studies to make a recommendation because the only study is open-label. BH4, tetrahydrobiopterin; FA, folinic acid; FRAA, folate receptor alpha autoantibody; IVIG, intravenous immunoglobulin; mB12, methyl-B12; MRS, magnetic resonance spectroscopy; pNN50, proportion of successive R–R intervals differing by more than 50 ms; RMSSD, root mean square differences of adjacent R–R intervals; rsfMRI, resting state functional MRI.