Table 4. Multivariate analysis in the training set.
| Variables | Multivariate analysis | |
|---|---|---|
| HR (95% CI) | P value | |
| Age at diagnosis | ||
| 30–50 | Reference | |
| 50–70 | 1.242 (0.802–1.923) | 0.331 |
| ≥70 | 2.107 (1.363–3.255) | <0.001 |
| T | ||
| T1 | Reference | |
| T2 | 1.259 (0.831–1.907) | 0.277 |
| T3 | 2.606 (1.710–3.917) | <0.001 |
| T4 | 4.017 (2.235–7.218) | <0.001 |
| M | ||
| M0 | Reference | |
| M1 | 2.347 (1.841-2.991) | <0.001 |
| Grade | ||
| I | Reference | |
| II | 1.230 (0.862–1.753) | 0.252 |
| III | 1.382 (0.957–1.994) | 0.083 |
| IV | 2.294 (1.324–3.957) | 0.003 |
| Tumor size (cm) | ||
| <3 | Reference | |
| 3–5 | 1.270 (1.003–1.607) | 0.046 |
| 5–10 | 1.418 (1.102–1.824) | 0.006 |
| ≥10 | 2.214 (1.384–3.540) | <0.001 |
| Histology | ||
| Adenomas and adenocarcinomas | Reference | |
| Others | 1.181 (0.899–1.551) | 0.231 |
| LODDS system | ||
| LODDS 1 | Reference | |
| LODDS 2 | 1.762 (1.330–2.335) | <0.001 |
| LODDS 3 | 2.602 (1.957–3.457) | <0.001 |
| LODDS 4 | 3.967 (2.571–6.121) | <0.001 |
T, M stages come from AJCC. AJCC, American Joint Committee on Cancer.