Table 4. Copies of CART19 sequence in different tissues of NSG mice (copies/ng DNA).
| Tissues | d0 | d7 | d14 | d21 | d28 | d35 | d42 | d49 | d56 |
|---|---|---|---|---|---|---|---|---|---|
| Blood | N.D. | N.D. | N.D. | N.D. | 13.2±9.4 | 46.6±31.2 | 25.9±18.3 | 1,187.6±206.5 | 0±0 |
| Heart | N.D. | N.D. | N.D. | N.D. | 11.1±2.3 | 36.6±26.8 | 152.1±96.4 | 108.2±108.6 | 145.0 |
| Lungs | N.D. | 10.9±1.2 | 5.8±0.5 | 6.7±0.9 | 56.2±20.3 | 150.2±51.4 | 41.2±16.8 | 1,885.1±208.2 | 126.2±45.6 |
| Liver | N.D. | N.D. | N.D. | 4.59 | 30.6±11.9 | 89.2±18.4 | 28.5±10.3 | 244.6±124.0 | 223.0±110.0 |
| Kidneys | N.D. | N.D. | N.D. | N.D. | 36.7 | 38.2±13.8 | 39.6±24.4 | 227.0±145.0 | 411.1±202.1 |
| Spleen | N.D. | 6.1±0.7 | N.D. | N.D. | 34.3±8.1 | 83.9±27.9 | 19.5±3.5 | 755.5±224.0 | 46.1±36.9 |
| Brain | N.D. | N.D. | 8.62 | N.D. | 9.5±2.1 | 35.5±3.2 | 81.3±54.1 | 68.0±25.1 | N.D. |
| Stomach | N.D. | N.D. | N.D. | 35.16 | 7.3±0.8 | 8.0±1.3 | 3.7 | 470.8±370.2 | 34.6 |
| Duodenum | N.D. | N.D. | N.D. | N.D. | 10.3±0.6 | 9.2 | 8.8 | 91.7±45.0 | 28.7 |
| Uterus | N.D. | 4.97 | N.D. | N.D. | 16.6 | 8.5±2.5 | N.D. | 609.3±210.6 | 413.6 |
| Ovaries | N.D. | 59.2±30.8 | N.D. | N.D. | 12.1 | 32.3±17.6 | 38.3 | 1,490.9±284.8 | 767.9 |
| Testis | N.D. | N.D. | N.D. | N.D. | 6.4 | 84.9±51.0 | 5.0±0.0 | N.D. | N.D. |
| Epididymis | N.D. | N.D. | N.D. | N.D. | 12.7±4.3 | 4.9 | N.D. | N.D. | 5.7 |
| Bone marrow | N.D. | N.D. | N.D. | 8.6±0.9 | 88.8±46.4 | 98.2±49.7 | 8.9 | 980.4±274.4 | 53.1±23.5 |
| Adipose tissue | N.D. | N.D. | 280.99 | N.D. | 52.0±26.0 | 67.0±24.9 | 38.2±23.6 | 709.0±250.7 | N.D. |
| Skeletal muscle | N.D. | N.D. | N.D. | N.D. | 16.8±5.1 | 68.7±23.4 | 9.8±1.0 | 308.2±194.3 | 37.5 |
N.D., not defined.