Table 2. KEGG pathway enrichment analysis.
| Pathway ID | Description | Up-regulated genes | Down-regulated genes | Enrichment factor | P |
|---|---|---|---|---|---|
| CNE-2 vs. CR | |||||
| hsa00100 | Steroid biosynthesis | SQLE, LSS, MSMO1, TM7SF2, CYP2R1, CEL, FDFT1 | 2.7 | 0.0108 | |
| hsa04520 | Adherens junction | CDC42, FYN, LEF1, FGFR1, PARD3, PVRL1, SMAD4, PTPRJ, SNAI1, IGF1R, LMO7, CTNNB1, TCF7L2, INSR, ACTN1, SMAD3, TGFBR1, PTPRM, CSNK2A2, EGFR | ERBB2, CDH1, SORBS1, PTPRB | 2.5 | 5.78E-05 |
| hsa05219 | Bladder cancer | CXCL8, RPS6KA5, MDM2, MMP1, TYMP, HBEGF, RASSF1, EGFR | THBS1, ERBB2, MMP9 CDH1, ARAF | 2.44 | 0.002628 |
| hsa05213 | Endometrial cancer | LEF1, PIK3CD, CTNNB1, PIK3R1, TCF7L2, AKT3, AXIN2, EGFR | AKT2, APC2, PTEN, ERBB2, CDH1, ARAF, ELK1, PIK3R5 | 2.37 | 0.001392 |
| hsa05210 | Colorectal cancer | LEF1, TGFB3, SMAD4, PIK3CD, CTNNB1, PIK3R1, TCF7L2, BCL2, AKT3, JUN, SMAD3, TGFBR1, AXIN2, TGFB1 | AKT2, APC2, ARAF, CYCS, PIK3R5 | 2.36 | 0.000598 |
| hsa00051 | Fructose and mannose metabolism | HKDC1, ALDOC, DAK | ALDOB, PMM2, C12ORF5, FPGT, AKR1B10, TPI1 | 2.1 | 0.02581 |
| hsa05211 | Renal cell carcinoma | CDC42, ARNT2, TGFB3, GAB1, ETS1, PIK3CD, PIK3R1, AKT3, JUN, PAK1, TGFB1 | AKT2, TCEB2, CUL2, RAP1A, ARAF, PAK6, PIK3R5 | 2.07 | 0.003591 |
| hsa04512 | ECM-receptor interaction | COL4A6, HSPG2, CD44, COL4A5, ITGA1, THBS3, ITGB4, LAMA2, CD47, SPP1, LAMB2, ITGA5, TNC, COL6A2, ITGA3, COL4A1, COL6A1, COL4A2 | THBS1, GP6, ITGA9, ITGB1 | 2.07 | 0.001506 |
| hsa05100 | Bacterial invasion of epithelial cells | CDC42, SEPT6, CLTA, GAB1, PIK3CD, CTNNB1, PIK3R1, SEPT8, ITGA5, DNM3, CTTN, SHC4 | SEPT3, ARPC3, CAV2, CDH1, ITGB1, ARPC5L, ARHGEF26, PIK3R5 | 1.98 | 0.003974 |
| hsa03320 | PPAR signaling pathway | PLIN2, EHHADH, SLC27A1, CPT1C, MMP1, ACOX3, ACSL4, PPARD, PPARA, PCK1, PCK2, ADIPOQ, ACSL5 | OLR1, FABP5, RXRA, SORBS1, SLC27A2 | 1.93 | 0.007707 |
| CR vs. CR-MLKL KO | |||||
| hsa00740 | Riboflavin metabolism | RFK, TYR | 3.66 | 0.03656 | |
| hsa00730 | Thiamine metabolism | ALPI, ALPP, AK1, ALPPL2, NTPCR, THTPA | 2.74 | 0.01473 | |
| hsa04350 | TGF-beta signaling pathway | ID2, ID3, BAMBI, SMAD2, BMP2, SMAD6, SMAD9, INHBB, CREBBP | BMP5, TGFB3, SMURF1, TGFB2, THBS1, ID4, DCN, SMAD4, BMPR1B, RBL1, FST, ACVR1B, ZFYVE16, TGFB1, SMURF2, TGFBR1, SMAD3, INHBA | 2.35 | 6.27E-05 |
| hsa05219 | Bladder cancer | MMP9, CDH1 | RPS6KA5, THBS1, CXCL8, ERBB2, FGFR3, MDM2, VEGFA, HBEGF, MMP1, TYMP, EGFR | 2.32 | 0.004185 |
| hsa00531 | Glycosaminoglycan degradation | HYAL3, ARSB | HEXA, IDUA, IDS, SGSH | 2.31 | 0.03468 |
| hsa04520 | Adherens junction | FYN, SMAD2, CREBBP, CDH1, PTPRB, SORBS1 | MET, CDC42, LEF1, ERBB2, RAC2, CTNNB1, FGFR1, PVRL1, BAIAP2, SMAD4, SSX2IP, PTPRF, TCF7L2, EGFR, TGFBR1, SMAD3, PTPRM | 2.27 | 0.00032 |
| hsa05210 | Colorectal cancer | APC2, SMAD2, GSK3B, BAX | TGFB3, TGFB2, LEF1, RAC2, CTNNB1, SMAD4, JUN, PIK3R1, FOS, RALGDS, TCF7L2, TGFB1, APC, TGFBR1, SMAD3 | 2.24 | 0.001124 |
| hsa04512 | ECM-receptor interaction | ITGB1 | CD44, COL4A5, THBS3, THBS1, HSPG2, CD47, ITGA6, LAMB1, LAMC3, LAMA3, ITGB4, ITGA5, LAMC2, TNC, ITGA3, COL6A2, SPP1, LAMA4, LAMB3, ITGA2, COL6A1, COL4A2, COL4A1 | 2.14 | 0.000589 |
| hsa05216 | Thyroid cancer | CDH1, RXRA | RXRB, LEF1, CTNNB1, TFG, TPM3, TCF7L2 | 2.02 | 0.04142 |
| hsa05211 | Renal cell carcinoma | CUL2, TCEB2, RAP1A, CREBBP | PDGFB, ARNT2, TGFB3, MET, TGFB2, CDC42, VHL, GAB1, VEGFA, JUN, PIK3R1, TGFB1, SLC2A1, PAK1 | 1.97 | 0.006236 |
DEGs, differentially expressed genes; KEGG, Kyoto encyclopedia of genes and genomes.